Category: "Column3"

Source: Bloomberg

Source: NYT

Source : Nature , a Schematic of the mRNA-RBD vaccine design. The SARS-CoV-2 mRNA encodes the signal peptide (SP), receptor-binding domain (RBD) from SARS-CoV-2 strain Wuhan/IVDC-HB-01/2019. b mRNA-RBD was transfected into HEK293T cells. RBD expression in the cell lysate and supernatant was analyzed by western blotting. c Particle size of LNPs by dynamic light scattering. d A representative cryo-electron microscopy image of a LNPs solution following mRNA encapsulation. Scale bar, 100 nm. e Zeta potential for LNPs at pH 4.0 and 7.4

Source : The Lancet , (A) Receptor-binding domain-specific antibodies on day 42, as measured by ELISA, in participants administered with vaccine, by age group and overall, or placebo overall. (B) Neutralising antibodies on day 42, as measured by neutralisation assay with 100 TCID50, in participants administered with vaccine or placebo.

Sources: Sheva, Pettersson, Duke, UN

Source : tandfonline

Source : PNAS

Source : AJNR

Source : Medrxiv

Source : Science

Source : Science

Source: Biorxiv , (A) Schematic of SARS-CoV-2 envelope protein (S2-E) delivered using amphipols for membrane protein insertion into planar lipid bilayers. (B) Representative single-channel current recordings of PMAL-C8 (C) The S2-E currentvoltage relationship

Source : Biorxiv , (A) The region in which the amino acid 614 was localized (square) on the trimer of Spike molecules (B) Predicted residue interactions with electrostatic (middle panels) and lipophibic (right panels) properties were compared between Spike D614 and G614 variants. (C) Sera from COVID-19 patients developing mild (blue, n=17), moderate (green, n=13) (D) Percentage of patients with decreased seropositivity against D614 and G614 variants from the different groups were presented.

Source: Wikipedia

Source : Indian Ministry of Health and Family Welfare

Source : ScienceMag

Source : News Medical A) Schematic of vaccine components which were RBD-Fe, S1-Fe and ECD-Fe. Fe: Ferritin, RBD: receptor-binding domain, ECD: ectodomain. (B) Schematic of nanoparticle of the three vaccines. PyMOL software was used for visualization14. (C) Western Blot analysis of the products prepared in silkworm by using an anti-RBD antibody. (D) ELISA of the S proteins to evaluate the expression levels. ECD-Fe with 287 ug/mL larval haemolymph, S1-Fe with 468 ug/mL larval haemolymph, RBD-Fe with 187 ug/mL larval haemolymph. (E) TEM image and two-dimensional (2D) reconstruction confirmed the successful assembly of each nanoparticle, IEM confirmed the S protein on the surface of the nanoparticle.

Source : AJNR , A, NCCT on the day of admission demonstrates subtle findings of acute ischemia in the right MCA (arrowheads) and bilateral ACA (arrows) territories, including hypoattenuation and loss of gray-white differentiation. B, Repeat NCCT on hospital day 2 demonstrates progression of acute infarcts in the right MCA and bilateral ACA territories, including worsening edema and mass effect.